A Rationally Optimized Nanoparticle System for the Delivery of RNA Interference Therapeutics into Pancreatic Tumors in Vivo

Author:

Teo Joann12,McCarroll Joshua A.12,Boyer Cyrille23,Youkhana Janet4,Sagnella Sharon M.12,Duong Hien T. T.23,Liu Jie4,Sharbeen George4,Goldstein David45,Davis Thomas P.67,Kavallaris Maria128,Phillips Phoebe A.24

Affiliation:

1. Tumour Biology and Targeting Program, Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Australia, Sydney, New South Wales 2052, Australia

2. Australian Centre for NanoMedicine, UNSW Australia, Sydney, New South Wales 2052, Australia

3. Centre for Advanced Macromolecular Design, School of Chemical Engineering, UNSW Australia, Sydney, New South Wales 2052, Australia

4. Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, UNSW Australia, Sydney, New South Wales 2052, Australia

5. Prince of Wales Hospital, Prince of Wales Clinical School, Sydney, New South Wales 2052, Australia

6. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences, Monash University, Clayton, Victoria 3800, Australia

7. Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom

8. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology UNSW Australia, Sydney, New South Wales 2052, Australia

Funder

National Health and Medical Research Council

Cancer Institute NSW

Australian Research Council

Cure Cancer Australia Foundation

Cancer Council NSW

University of New South Wales

Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Research Council

Balnaves Foundation

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

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