PEtOxylated Interferon-α2a Bioconjugates Addressing H1N1 Influenza A Virus Infection

Author:

Hauptstein Niklas1ORCID,Dirauf Michael23,Wittwer Kevin4,Cinar Gizem23,Siering Oliver4,Raschig Martina1,Lühmann Tessa1ORCID,Scherf-Clavel Oliver1,Sawatsky Bevan4ORCID,Nischang Ivo23ORCID,Schubert Ulrich S.23ORCID,Pfaller Christian K.4,Meinel Lorenz15ORCID

Affiliation:

1. Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

2. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743 Jena, Germany

3. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany

4. Paul-Ehrlich-Institute, Division of Veterinary Medicine, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany

5. Helmholtz Institute for RNA−Based Infection Research (HIRI), Josef-Schneider-Straße 2, 97080 Würzburg, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Th?ringer Aufbaubank

Freistaat Th?ringen

European Regional Development Fund

European Social Fund

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Reference53 articles.

1. Bioconjugation strategies and clinical implications of Interferon-bioconjugates

2. EMA. Pegasys INN-Peginterferon alpha 2a. https://www.ema.europa.eu/en/documents/product-information/pegasys-epar-product-information_en.pdf (accessed June 5, 2022).

3. EMA. PegIntron 50 micrograms powder and solvent for solution for injection. https://ec.europa.eu/health/documents/community-register/2016/20160629135304/anx_135304_en.pdf (accessed June 5, 2022).

4. EMA. Besremi 250 micrograms/0.5 mL solution for injection in pre-filled pen. https://www.ema.europa.eu/en/documents/product-information/besremi-epar-product-information_en.pdf (accessed June 5, 2022).

5. Decoding type I and III interferon signalling during viral infection

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