Red Blood Cell Cryopreservation with Minimal Post-Thaw Lysis Enabled by a Synergistic Combination of a Cryoprotecting Polyampholyte with DMSO/Trehalose

Author:

Murray Alex1ORCID,Congdon Thomas R.1,Tomás Ruben M. F.12ORCID,Kilbride Peter3,Gibson Matthew I.12ORCID

Affiliation:

1. Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

2. Warwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.

3. Asymptote, Cytiva, Chivers Way, Cambridge CB24 9BZ, U.K.

Funder

Engineering and Physical Sciences Research Council

Royal Society

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

University of Warwick

Cytivia

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering

Reference84 articles.

1. Walters, G. SPECIFICATION SPN223/8 NHSBT Portfolio of Blood Components and Guidance for Their; Clinical Use, 2016.

2. Transfusion of Cryopreserved Packed Red Blood Cells Is Safe and Effective After Trauma

3. Australian experience with frozen blood products on military operations

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