Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine: Effects on pKa, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth-Reference-Cited by-同舟云学术

Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine: Effects on pKa, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth

Published:2003-06-06 Issue:14 Volume:46 Page:3166-3169
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheruku Srinivasa R.¹,Maiti Souvik¹,Dorn Arnulf¹,Scorneaux Bernard¹,Bhattacharjee Apurba K.¹,Ellis William Y.¹,Vennerstrom Jonathan L.¹

Affiliation:

1. College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198-6025; Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; Swiss Tropical Institute, CH-4002 Basel, Switzerland; and Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, D. C. 20307-5100

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030038x

Reference34 articles.

1. Mechanism of malarial haem detoxification inhibition by chloroquine

2. Photochemical studies of 7-cis-rhodopsin at low temperatures. Nature and properties of the bathointermediate

3. Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

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