Synthesis and Biological Activity of Conformationally Restricted Analogs of Milnacipran: (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an Efficient Noncompetitive N-Methyl-d-aspartic Acid Receptor Antagonist-Reference-Cited by-同舟云学术

Synthesis and Biological Activity of Conformationally Restricted Analogs of Milnacipran: (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide, an Efficient Noncompetitive N-Methyl-d-aspartic Acid Receptor Antagonist

Published:1996-01-01 Issue:24 Volume:39 Page:4844-4852
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shuto Satoshi¹,Ono Shizuka¹,Hase Yukako¹,Ueno Yoshihito¹,Noguchi Tomohiro¹,Yoshii Kiyonori¹,Matsuda Akira¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan, and Department of Biochemical Engineering and Science, Kyushu Institute of Technology, Iizuka 820, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960495w

Reference31 articles.

1. Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

2. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

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