Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy

Author:

Denison Madeline1,Steinke Sean J.2,Majeed Aliza3,Turro Claudia2ORCID,Kocarek Thomas A.3,Sevrioukova Irina F.4ORCID,Kodanko Jeremy J.15ORCID

Affiliation:

1. Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States

2. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States

3. Institute of Environmental Health Sciences, Wayne State University, 6135 Woodward Avenue, Integrative Biosciences Center, Room 2126, Detroit, Michigan 48202, United States

4. Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States

5. Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States

Funder

U.S. Department of Health and Human Services

National Science Foundation

U.S. Department of Energy

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

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