Sc-HOPO: A Potential Construct for Use in Radioscandium-Based Radiopharmaceuticals

Author:

Phipps Michael D.1234,Cingoranelli Shelbie5,Bhupathiraju N. V. S. Dinesh K.2ORCID,Younes Ali2ORCID,Cao Minhua2,Sanders Vanessa A.6,Neary Michelle C.2ORCID,Devany Matthew H.2,Cutler Cathy S.6,Lopez Gustavo E.13ORCID,Saini Shefali5,Parker Candace C.5ORCID,Fernandez Solana R.5,Lewis Jason S.4ORCID,Lapi Suzanne E.5,Francesconi Lynn C.12ORCID,Deri Melissa A.13ORCID

Affiliation:

1. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York10016, United States

2. Department of Chemistry, City University of New York Hunter College, 695 Park Avenue, New York, New York10065, United States

3. Department of Chemistry, Lehman College of the City University of New York, Bronx, New York10468, United States

4. Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York10065, United States

5. Department of Radiology, University of Alabama at Birmingham (UAB), Birmingham, Alabama35294, United States

6. Medical Isotope Research and Production Laboratory, Collider−Accelerator Division, Brookhaven National Laboratory (BNL), Upton, New York11973, United States

Funder

Tow Foundation

Hunter College

U.S. Department of Energy

National Institute of General Medical Sciences

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Inorganic Chemistry,Physical and Theoretical Chemistry

Reference50 articles.

1. FDA-approved radiopharmaceuticals 2022. https://www.cardinalhealth.com/content/dam/corp/web/documents/fact-sheet/cardinal-health-fda-approved-radiopharmaceuticals.pdf (accessed 10/19/2022).

2. Information extracted from the NuDat Database, National Nuclear Data Center, 2021.

3. Promising Prospects for 44Sc-/47Sc-Based Theragnostics: Application of 47Sc for Radionuclide Tumor Therapy in Mice

4. Scandium(iii) complexes of monophosphorus acid DOTA analogues: a thermodynamic and radiolabelling study with 44Sc from cyclotron and from a 44Ti/44Sc generator

5. 44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

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