Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity-Reference-Cited by-同舟云学术

Overcoming Undesirable CYP1A2 Inhibition of Pyridylnaphthalene-Type Aldosterone Synthase Inhibitors: Influence of Heteroaryl Derivatization on Potency and Selectivity

Published:2008-08-01 Issue:16 Volume:51 Page:5064-5074
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heim Ralf¹,Lucas Simon¹,Grombein Cornelia M.¹,Ries Christina¹,Schewe Katarzyna E.¹,Negri Matthias¹,Birk Barbara¹,Hartmann Rolf W.¹

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 151150, D-66041 Saarbrücken, Germany, Pharmacelsus CRO, Science Park 2, D-66123 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800377h

Reference75 articles.

1. Vascular synthesis of aldosterone: role in hypertension

2. Extra-adrenal production of corticosteroids

3. Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

4. Renin–angiotensin–aldosterone system and myocardial fibrosis

5. Induction of Cardiac Fibrosis by Aldosterone

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