1. Laboratory of Molecular Gerontology, National Institutes on Aging, National Institutes of Health, Baltimore, Maryland 21224, Novartis Horsham Research Centre, Horsham, West Sussex, RH12 4AB United Kingdom, Novartis Pharma, Ltd., 4002 Basel, Switzerland, and Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205