Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy-Reference-Cited by-同舟云学术

Identification of Novel, Water-Soluble, 2-Amino-N-pyrimidin-4-yl Acetamides as A2A Receptor Antagonists with In Vivo Efficacy

Published:2008-01-12 Issue:3 Volume:51 Page:400-406
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Slee Deborah H.¹,Zhang Xiaohu¹,Moorjani Manisha¹,Lin Emily¹,Lanier Marion C.¹,Chen Yongsheng¹,Rueter Jaimie K.¹,Lechner Sandra M.¹,Markison Stacy¹,Malany Siobhan¹,Joswig Tanya¹,Santos Mark¹,Gross Raymond S.¹,Williams John P.¹,Castro-Palomino Julio C.¹,Crespo María I.¹,Prat Maria¹,Gual Silvia¹,Díaz José-Luis¹,Wen Jenny¹,O’Brien Zhihong¹,Saunders John¹

Affiliation:

1. Departments of Medicinal Chemistry, Pharmacology and Lead Discovery, Neuroscience, Chemical Development and Preclinical Development, Neurocrine Biosciences, 12790 El Camino Real, San Diego, California 92130, and Almirall Research Center, Almirall, Ctra. Laureà Miró, 408-410, E-08980 St. Feliu de Llobregat, Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070623o

Reference25 articles.

1. Distribution, biochemistry and function of striatal adenosine A2A receptors

2. Recent developments in the pharmacological treatment of Parkinson’s disease

3. Blockade of Striatal Adenosine A2AReceptor Reduces, through a Presynaptic Mechanism, Quinolinic Acid-Induced Excitotoxicity: Possible Relevance to Neuroprotective Interventions in Neurodegenerative Diseases of the Striatum

4. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

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