A New Approach to Explore the Binding Space of Polysaccharide-Based Ligands: Selectin Antagonists
Author:
Affiliation:
1. Département de Chimie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Québec H3C 3J7, Canada
2. Department of Chemistry, McGill University, Montréal, Québec H3A 2K6, Canada
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ml300263x
Reference30 articles.
1. Endothelial-Leukocyte Adhesion Molecules
2. Targeting selectins and selectin ligands in inflammation and cancer
3. GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice
4. E-selectin as a target for drug delivery and molecular imaging
5. Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1
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