1. Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Ikeda, Kumamoto 860-0082, Japan, School of Agriculture, Tokai University, 5435, Aso, Kumamoto 869-1404, Japan, Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan, and Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan