Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis-Reference-Cited by-同舟云学术

Discovery Tactics To Mitigate Toxicity Risks Due to Reactive Metabolite Formation with 2-(2-Hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives, Potent Calcium-Sensing Receptor Antagonists and Clinical Candidate(s) for the Treatment of Osteoporosis

Published:2010-05-27 Issue:6 Volume:23 Page:1115-1126
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kalgutkar Amit S.¹,Griffith David A.¹,Ryder Tim¹,Sun Hao¹,Miao Zhuang¹,Bauman Jonathan N.¹,Didiuk Mary T.¹,Frederick Kosea S.¹,Zhao Sabrina X.¹,Prakash Chandra¹,Soglia John R.¹,Bagley Scott W.¹,Bechle Bruce M.¹,Kelley Ryan M.¹,Dirico Kenneth¹,Zawistoski Michael¹,Li Jianke¹,Oliver Robert¹,Guzman-Perez Angel¹,Liu Kevin K. C.¹,Walker Daniel P.¹,Benbow John W.¹,Morris Joel¹

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism Department and Department of Medicinal Chemistry, Pfizer Global Research and Development, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx100137n

Reference41 articles.

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3. Molecular Cloning and Functional Expression of Human Parathyroid Calcium Receptor cDNAs

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5. A Novel Calcium-Sensing Receptor Antagonist Transiently Stimulates Parathyroid Hormone Secretion in Vivo

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