Enantiospecific Total Synthesis of l-2‘,3‘-Dideoxyisonucleosides via Regioselective Opening of Optically Active C2-Symmetric 1,4-Pentadiene Bis-epoxide1-Reference-Cited by-同舟云学术

Enantiospecific Total Synthesis of l-2‘,3‘-Dideoxyisonucleosides via Regioselective Opening of Optically Active C2-Symmetric 1,4-Pentadiene Bis-epoxide1

Published:1998-04-02 Issue:9 Volume:63 Page:2975-2981
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Jung Michael E.¹,Kretschik Oliver¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo9721655

Reference25 articles.

1. Presented in part at the 2nd AFMC International Medicinal Chemistry Symposium (AIMECS 97), Seoul, Korea, July 1997.

2. Deutsche Forschungsgemeinschaft Fellow, 1996−1997.

3. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

4. Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

5. Biochemical pharmacology of (+)- and (-)-2',3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents.

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