Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors-Reference-Cited by-同舟云学术

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

Published:2013-05-10 Issue:10 Volume:56 Page:3889-3903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Peng Yi-Hui¹,Shiao Hui-Yi¹,Tu Chih-Hsiang¹²,Liu Pang-Min¹,Hsu John Tsu-An¹,Amancha Prashanth Kumar¹,Wu Jian-Sung¹,Coumar Mohane Selvaraj³,Chen Chun-Hwa¹,Wang Sing-Yi¹,Lin Wen-Hsing¹,Sun Hsu-Yi¹,Chao Yu-Sheng¹,Lyu Ping-Chiang²,Hsieh Hsing-Pang¹,Wu Su-Ying¹

Affiliation:

1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC

2. Institute of Bioinformatics and Structural Biology, National Tsing Hua University, 101, Sect. 2, Guangfu Road, Hsinchu 300, Taiwan, ROC

3. Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400072p

Reference71 articles.

1. The Protein Kinase Complement of the Human Genome

2. Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation

3. Targeting cancer with small molecule kinase inhibitors