Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency-Reference-Cited by-同舟云学术

Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency

Published:2012-01-12 Issue:2 Volume:55 Page:783-796
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Borthwick Alan D.,Liddle John,Davies Dave E.,Exall Anne M.,Hamlett Christopher,Hickey Deirdre M.,Mason Andrew M.,Smith Ian E. D.,Nerozzi Fabrizio,Peace Simon,Pollard Derek,Sollis Steve L.,Allen Michael J.¹,Woollard Patrick M.,Pullen Mark A.²,Westfall Timothy D.²,Stanislaus Dinesh J.³

Affiliation:

1. Department of Assay Development and Compound Profiling, Harlow Research 2, GlaxoSmithKline, New Frontiers, Science Park, Third Avenue, Harlow, Essex CM19 5AD, U.K.

2. Department of Urogenital Biology, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, United States

3. Safety Assessment, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201287w

Reference20 articles.

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3. Treatment of preterm labor with the oxytocin and vasopressin antagonist Atosiban

4. Oral Oxytocin Antagonists

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