Cyclopentenone Prostaglandin, 15-Deoxy-Δ12,14-PGJ2, Is Metabolized by HepG2 Cells via Conjugation with Glutathione-Reference-Cited by-同舟云学术

Cyclopentenone Prostaglandin, 15-Deoxy-Δ12,14-PGJ2, Is Metabolized by HepG2 Cells via Conjugation with Glutathione

Published:2007-09-14 Issue:10 Volume:20 Page:1528-1535
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Brunoldi Enrico M.¹,Zanoni Giuseppe¹,Vidari Giovanni¹,Sasi Soumya¹,Freeman Michael L.¹,Milne Ginger L.¹,Morrow Jason D.¹

Affiliation:

1. Departments of Medicine and Pharmacology and Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx700231a

Reference25 articles.

1. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.

2. Induction ofMRP/GS-X pump and cellular resistance to anticancer prostaglandins

3. Intracellular glutathione level modulates the induction of apoptosis by Δ12-prostaglandin J2

4. Cyclopentenone Prostaglandins as Potential Inducers of Intracellular Oxidative Stress

5. Formation of a prostaglandin A2-glutathione conjugate in L1210 mouse leukemia cells

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