Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice-Reference-Cited by-同舟云学术

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity in Mice

Published:2011-05-12 Issue:11 Volume:54 Page:3935-3949
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gujjar Ramesh,El Mazouni Farah¹,White Karen L.²,White John,Creason Sharon,Shackleford David M.²,Deng Xiaoyi¹,Charman William N.²,Bathurst Ian³,Burrows Jeremy³,Floyd David M.³,Matthews David³,Buckner Frederick S.,Charman Susan A.²,Phillips Margaret A.¹,Rathod Pradipsinh K.

Affiliation:

1. Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, Texas 75390-9041, United States

2. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia

3. Medicines for Malaria Venture, Geneva, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200265b

Reference34 articles.

1. Malaria: progress, perils, and prospects for eradication

2. Shrinking the malaria map: progress and prospects

3. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

4. Antimalarial drug resistance

5. The Selection Landscape of Malaria Parasites

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