1. Graduate Institute of Pharmaceutical Sciences, Graduate Institute of Biochemistry, Faculty of Biotechnology, Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Biological Science and Technology, Chung Hwa College of Medical Technology, Tainan, Taiwan, Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, and National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung, Taiwan