2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,-Reference-Cited by-同舟云学术

2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,

Published:2003-01-24 Issue:6 Volume:42 Page:1430-1438
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Watkins Ryan E.¹,Maglich Jodi M.¹,Moore Linda B.¹,Wisely G. Bruce¹,Noble Schroeder M.¹,Davis-Searles Paula R.¹,Lambert Mill H.¹,Kliewer Steven A.¹,Redinbo Matthew R.¹

Affiliation:

1. Departments of Chemistry and Biochemistry & Biophysics and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, North Carolina 27599, and Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi0268753

Reference56 articles.

1. Regulation of CYP3A Gene Transcription by the Pregnane X Receptor

2. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

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