1. Hokkaido Pharmaceutical University School of Pharmacy, 7-1, Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan, Laboratory of Chemical Biology, Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, Faculty of Pharmaceutical Sciences, Musashino University, 1-1-20, Shinmachi, Nishitokyo-shi, Tokyo 202-8585, Japan