Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1-Reference-Cited by-同舟云学术

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

Published:2019-01-15 Issue:6 Volume:141 Page:2404-2412
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ural-Blimke Yonca¹,Flayhan Ali¹,Strauss Jan¹^ORCID,Rantos Vasileios¹,Bartels Kim¹,Nielsen Rolf¹,Pardon Els²³,Steyaert Jan²³,Kosinski Jan¹⁴,Quistgaard Esben M.¹⁵⁶,Löw Christian¹⁵^ORCID

Affiliation:

1. Centre for Structural Systems Biology (CSSB), DESY and European Molecular Biology Laboratory Hamburg, Notkestrasse 85, D-22607 Hamburg, Germany

2. Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels 1050, Belgium

3. VIB-VUB Center for Structural Biology, VIB, Brussels 1050, Belgium

4. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

5. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, SE-17177 Stockholm, Sweden

6. Department of Molecular Biology and Genetics − DANDRITE, Gustav Wieds Vej 10, Aarhus University, DK-8000 Aarhus C, Denmark

Funder

Vetenskapsrådet

German-Israeli Foundation for Scientific Research and Development

H2020 Marie Sklodowska-Curie Actions

H2020 Research Infrastructures

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.8b11343

Reference47 articles.

1. Pharmaceutical and pharmacological importance of peptide transporters

2. Single-Dose Pharmacokinetics of Valganciclovir in HIV- and CMV-Seropositive Subjects

3. Amino Acid Ester Prodrugs of Acyclovir

4. Functional and Structural Characterization of a Prokaryotic Peptide Transporter with Features Similar to Mammalian PEPT1

5. Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

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