Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion-Reference-Cited by-同舟云学术

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Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

Published:2018-11-14 Issue:48 Volume:140 Page:16428-16432
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Burslem George M.¹^ORCID,Song Jayoung¹,Chen Xin²,Hines John¹,Crews Craig M.¹³^ORCID

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, United States

2. Arvinas Inc., New Haven, Connecticut 06511, United States

3. Departments of Chemistry and Pharmacology, Yale University, New Haven, Connecticut 06520, United States

Funder

National Cancer Institute

National Research Foundation of Korea

Leukemia and Lymphoma Society

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.8b10320

Reference40 articles.

1. Small-Molecule Modulation of Protein Homeostasis

2. Waste disposal—An attractive strategy for cancer therapy

3. Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy

4. Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway

5. Proteolysis-Targeting Chimeras: Harnessing the Ubiquitin-Proteasome System to Induce Degradation of Specific Target Proteins

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