1. Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan, Chugai Pharmaceutical Co. Ltd, Fuji Gotemba Research Laboratories, 135 Komakado-1 chome, Gotemba-shi, 412-8513, Japan, and Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control and First Department of Surgery, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan