Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice-Reference-Cited by-同舟云学术

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

Published:2009-03-18 Issue:7 Volume:52 Page:1864-1872
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gujjar Ramesh¹,Marwaha Alka¹,El Mazouni Farah¹,White John¹,White Karen L.¹,Creason Sharon¹,Shackleford David M.¹,Baldwin Jeffrey¹,Charman William N.¹,Buckner Frederick S.¹,Charman Susan¹,Rathod Pradipsinh K.¹,Phillips Margaret A.¹

Affiliation:

1. Department of Chemistry and Global Health and Department of Medicine, University of Washington, Seattle, Washington 98195, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, Texas 75390-9041, and Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC 3052, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801343r

Reference36 articles.

1. Malaria: progress, perils, and prospects for eradication

2. The Limits and Intensity of Plasmodium falciparum Transmission: Implications for Malaria Control and Elimination Worldwide

3. Antimalarial drug resistance

4. Artesunate for the Treatment of Severe Falciparum Malaria

5. Genome sequence of the human malaria parasite Plasmodium falciparum

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