Method To Visualize the Intratumor Distribution and Impact of Gemcitabine in Pancreatic Ductal Adenocarcinoma by Multimodal Imaging

Author:

Strittmatter Nicole12ORCID,Richards Frances M.34,Race Alan M.5ORCID,Ling Stephanie1ORCID,Sutton Daniel1,Nilsson Anna67,Wallez Yann38,Barnes Jennifer1,Maglennon Gareth1,Gopinathan Aarthi3,Brais Rebecca9,Wong Edmond10,Serra Maria Paola1,Atkinson James1,Smith Aaron11,Wilson Joanne11,Hamm Gregory1,Johnson Timothy I.3,Dunlop Charles R.3,Kaistha Brajesh P.312,Bunch Josephine1314,Sansom Owen J.1516,Takats Zoltan1714ORCID,Andrén Per E.67ORCID,Lau Alan8,Barry Simon T.8,Goodwin Richard J. A.118,Jodrell Duncan I.319

Affiliation:

1. Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

2. Department of Chemistry, Technical University of Munich, 85748 Garching, Germany

3. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, U.K.

4. Translational Medicine, Oncology R&D, Astra Zeneca, Cambridge CB4 0WG, United Kingdom

5. Institute of Medical Bioinformatics and Biostatistics, Philipps University of Marburg, 35032 Marburg, Germany

6. Department of Pharmaceutical Biosciences, Medical Mass Spectrometry Imaging, Uppsala University, 751 24 Uppsala, Sweden

7. Science for Life Laboratory, Spatial Mass Spectrometry, Uppsala University, 751 24 Uppsala, Sweden

8. Bioscience, Oncology R&D, AstraZeneca, Cambridge CB2 0RE, United Kingdom

9. Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, United Kingdom

10. Biologics Engineering, R&D, AstraZeneca, Cambridge CB12 6GH, United Kingdom

11. DMPK, Oncology R&D, AstraZeneca, Cambridge CB2 0RE, United Kingdom

12. Clinical IO group, Early Oncology, AstraZeneca, Cambridge CB12 6GH, United Kingdom

13. National Centre of Excellence in Mass Spectrometry Imaging, National Physical Laboratory, Teddington TW11 0LW, United Kingdom

14. Rosalind Franklin Institute, Didcot OX11 0QS, United Kingdom

15. Cancer Research UK Beatson Institute, Glasgow G61 1BD, United Kingdom

16. Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom

17. Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, United Kingdom

18. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, United Kingdom

19. Department of Oncology, University of Cambridge, Cambridge CB2 0XZ, United Kingdom

Funder

Forskningsr?det om H?lsa, Arbetsliv och V?lf?rd

Stiftelsen f?r?Strategisk Forskning

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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