Nontargeted High-Resolution Mass Spectrometric Workflow for the Detection of Butyrylcholinesterase-Derived Adducts with Organophosphorus Toxicants and Structural Characterization of Their Phosphyl Moiety after In-Source Fragmentation

Author:

John Harald1ORCID,Dentzel Marina1,Siegert Markus12,Thiermann Horst1

Affiliation:

1. Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 Munich, Germany

2. Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Straße 2, 12489 Berlin, Berlin, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference29 articles.

1. John, H.; Balszuweit, F.; Steinritz, D.; Kehe, K.; Worek, F.; Thiermann, H. Handbook of Toxicology of Chemical Warfare Agents, 3rd ed. Gupta, R., Ed. Elsevier Inc./Academic Press: San Diego, 2020; pp 875–929.

2. Chemical Weapons Convention: Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction; The Organisation for the Prohibition of Chemical Weapons (OPCW): The Hague. The Netherlands, 2020. https://www.opcw.org/sites/default/files/documents/CWC/CWC_en.pdf (accessed August 11, 2021).

3. Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network

4. Statement by H.E. Ambassador Kenneth D. W. Permanent Representative of the United States of America to the OPCW in Response to the Director-Generaĺs Presentation of the Report of the OPCW Investigation and Identification Team for Syria; The Organisation for the Prohibition of Chemical Weapons (OPCW): The Hague. The Netherlands. https://www.opcw.org/sites/default/files/documents/2020/04/IIT%20Report%20USA%20National%20Statement%2004082020.pdf (accessed 11 August, 2021).

5. Murders with VX: Aum Shinrikyo in Japan and the assassination of Kim Jong-Nam in Malaysia

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