Metabolite Identification Using Infrared Ion Spectroscopy─Novel Biomarkers for Pyridoxine-Dependent Epilepsy

Author:

van Outersterp Rianne E.1,Engelke Udo F.H.2,Merx Jona3,Berden Giel1ORCID,Paul Mathias4,Thomulka Thomas4,Berkessel Albrecht4ORCID,Huigen Marleen C.D.G.2,Kluijtmans Leo A.J.2ORCID,Mecinović Jasmin5ORCID,Rutjes Floris P.J.T.3ORCID,van Karnebeek Clara D.M.6,Wevers Ron A.2,Boltje Thomas J.3ORCID,Coene Karlien L.M.2,Martens Jonathan1ORCID,Oomens Jos17ORCID

Affiliation:

1. Institute for Molecules and Materials, FELIX Laboratory, Radboud University, Toernooiveld 7, 6525 ED Nijmegen, The Netherlands

2. Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands

3. Institute for Molecules and Materials, Synthetic Organic Chemistry, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands

4. Department of Chemistry, University of Cologne, Greinstrasse 4, 50939 Cologne, Germany

5. University of Southern Denmark, Department of Physics, Chemistry and Pharmacy, Campusvej 55, 5230 Odense, Denmark

6. Department of Pediatrics-Metabolic Diseases, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands

7. van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 908, 1098XH Amsterdam, The Netherlands

Funder

Radboud Universiteit

H2020 European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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