Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry-Reference-Cited by-同舟云学术

Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry

Published:2018-03-01 Issue:7 Volume:90 Page:4669-4676
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Füssl Florian¹,Cook Ken²,Scheffler Kai³,Farrell Amy¹,Mittermayr Stefan¹^ORCID,Bones Jonathan¹⁴^ORCID

Affiliation:

1. NIBRT−The National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Blackrock, Co. Dublin, A94 X099, Ireland

2. Thermo Fisher Scientific, Stafford House, 1 Boundary Park, Hemel Hempstead, HP2 7GE, United Kingdom

3. Thermo Fisher Scientific, Dornierstrasse 4, 82110 Germering, Germany

4. School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, D04 V1W8, Ireland

Funder

Science Foundation Ireland

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.7b05241

Reference40 articles.

1. Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

2. Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

3. Identification of multiple sources of charge heterogeneity in a recombinant antibody

4. Ion-exchange chromatography for the characterization of biopharmaceuticals

5. Characterization of cation exchanger stationary phases applied for the separations of therapeutic monoclonal antibodies

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