Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies-Reference-Cited by-同舟云学术

Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies

Published:2016-11-11 Issue:23 Volume:88 Page:11521-11526
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Tran John C.¹,Tran Daniel¹,Hilderbrand Amy¹,Andersen Nisana¹,Huang Tao¹,Reif Karin¹,Hotzel Isidro¹,Stefanich Eric G.¹,Liu Yichin¹,Wang Jianyong¹

Affiliation:

1. Biochemical and Cellular Pharmacology, ‡Protein Analytical Chemistry, §Immunology, ∥Antibody Engineering, and ⊥Preclinical and Translational Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080-4990, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b02766

Reference34 articles.

1. Succinimide Formation from Aspartyl and Asparaginyl Peptides as a Model for the Spontaneous Degradation of Proteins

2. Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein

3. Deamidation of human proteins

4. Characterization of Therapeutic Antibodies and Related Products

5. Developability Assessment During the Selection of Novel Therapeutic Antibodies

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