Comprehensive Discovery and Quantitation of Protein Heterogeneity via LC-MS/MS Peptide Mapping for Clone Selection of a Therapeutic Protein
Author:
Affiliation:
1. Departments of †Analytical Development and ‡Cell Line Development, Shire, Lexington, Massachusetts United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b02895
Reference43 articles.
1. Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications
2. Characterization of Therapeutic Antibodies and Related Products
3. Characterization of Cysteinylation and Trisulfide Bonds in a Recombinant Monoclonal Antibody
4. Primary Sequence Confirmation of a Protein Therapeutic Using Top Down MS/MS and MS3
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