High-Throughput Lipidomic and Transcriptomic Analysis To Compare SP2/0, CHO, and HEK-293 Mammalian Cell Lines

Author:

Zhang Yue1,Baycin-Hizal Deniz2,Kumar Amit1ORCID,Priola Joseph1,Bahri Michelle1,Heffner Kelley M.1,Wang Miao3,Han Xianlin3,Bowen Michael A.2,Betenbaugh Michael J.1ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States

2. Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, Maryland 20878, United States

3. Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827, United States

Funder

MedImmune

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference39 articles.

1. Biopharmaceutical benchmarks 2014

2. Harnessing Chinese hamster ovary cell proteomics for biopharmaceutical processing

3. Li, F.; Vijayasankaran, N.; Shen, A.; Kiss, R.; Amanullah, A.InCell Culture Processes for Monoclonal Antibody Production, MAbs;Taylor & Francis, 2010; pp466–479.

4. Lipidomics: New Tools and Applications

5. Membrane lipids: where they are and how they behave

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