A Middle-Up Approach with Online Capillary Isoelectric Focusing/Mass Spectrometry for In-Depth Characterization of Cetuximab Charge Heterogeneity
Author:
Affiliation:
1. Separation and Analysis Technology Team, Bristol-Myers Squibb Research and Development, Post Office Box 4000, Princeton, New Jersey 08543, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b04396
Reference49 articles.
1. Front Cover: Interlaboratory method validation of icIEF methodology for analysis of monoclonal antibodies
2. High-resolution separation of monoclonal antibodies mixtures and their charge variants by an alternative and generic CZE method
3. Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development
4. Capillary isoelectric focusing-mass spectrometry: Coupling strategies and applications
5. Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants
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