Epitope Mapping by HDX-MS Elucidates the Surface Coverage of Antigens Associated with High Blocking Efficiency of Antibodies to Birch Pollen Allergen
Author:
Affiliation:
1. Regeneron Pharmaceuticals, 777 Old Saw Mill River Rd, Tarrytown, New York 10591, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b01864
Reference35 articles.
1. The gene coding for the major birch pollen allergen Betv1, is highly homologous to a pea disease resistance response gene.
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3. Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy
4. Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
5. Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
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