Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody-Reference-Cited by-同舟云学术

Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody

Published:2018-09-25 Issue:21 Volume:90 Page:12527-12535
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Srzentić Kristina¹,Nagornov Konstantin O.²,Fornelli Luca¹,Lobas Anna A.³,Ayoub Daniel¹,Kozhinov Anton N.²,Gasilova Natalia¹,Menin Laure¹,Beck Alain⁴,Gorshkov Mikhail V.³⁵,Aizikov Konstantin⁶,Tsybin Yury O.²^ORCID

Affiliation:

1. Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

2. Spectroswiss, EPFL Innovation Park, 1015 Lausanne, Switzerland

3. Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia

4. Centre d’Immunologie Pierre Fabre, 74160 St. Julien-en-Genevois, France

5. Moscow Institute of Physics and Technology State University, 141707 Dolgoprudny, Moscow Region, Russia

6. Thermo Fisher Scientific GmbH, 28199 Bremen, Germany

Funder

Russian Foundation for Basic Research

FP7 Ideas: European Research Council

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b02398

Reference46 articles.

1. How many human proteoforms are there?

2. Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

3. Characterization of Therapeutic Monoclonal Antibodies at the Subunit-Level using Middle-Down 193 nm Ultraviolet Photodissociation

4. Raw protein from the top down

5. Top-Down Proteomics: Ready for Prime Time?

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