Chemical Structure and Composition of Major Glycans Covalently Linked to Therapeutic Monoclonal Antibodies by Middle-Down Nuclear Magnetic Resonance
Author:
Funder
U.S. Food and Drug Administration
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b02637
Reference64 articles.
1. Therapeutic Monoclonal Antibodies Approved by FDA in 2016
2. Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins
3. Post-translational structural modifications of immunoglobulin G and their effect on biological activity
4. Optimal and consistent protein glycosylation in mammalian cell culture
5. Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs
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