Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s

Author:

Katz Lauren12,Kiyota Taira3,Woolman Michael12,Wu Megan4,Pires Layla1,Fiorante Alexa12,Ye Lan Anna1,Leong Wey56,Berman Hal K.57,Ghazarian Danny8,Ginsberg Howard J.1689,Das Sunit46,Aman Ahmed310ORCID,Zarrine-Afsar Arash1268ORCID

Affiliation:

1. Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada

2. Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON M5G 1L7, Canada

3. Ontario Institute for Cancer Research (OICR), 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada

4. Peter Gilgan Centre for Research and Learning & Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada

5. Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, ON M5G 2C1, Canada

6. Department of Surgery, University of Toronto, 149 College Street, Toronto, ON M5T 1P5, Canada

7. Department of Laboratory Medicine and Pathobiology, University of Toronto and the Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada

8. Keenan Research Center for Biomedical Science & the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada

9. Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King’s College Circle, Sixth Floor, Toronto, ON M5S 1A8, Canada

10. Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St, Toronto, ON M5S 3M2, Canada

Funder

Canadian Institutes of Health Research

Princess Margaret Cancer Foundation

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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