LC–MS/MS-Based Absolute Quantitation of Hemoglobin Subunits from Dried Blood Spots Reveals Novel Biomarkers for α-Thalassemia Silent Carriers

Author:

Ren Zhe12ORCID,Sun Guoying12,Zhang Qianqian34,Zou Shaomin3,Chen Jianhong5,Zhao Weining6,Hou Guixue12,Zhong Zeyan5,Li Jialong3,Ye Yuhua3,Xu Xiangmin37,Lin Liang12ORCID

Affiliation:

1. BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China

2. Clinical Laboratory of BGI Health, BGI-Shenzhen, Shenzhen 518083, China

3. Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China

4. Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan, Guangdong 523001, China

5. Department of Medical Genetics and Prenatal Diagnosis, Huizhou First Maternal and Child Health Care Hospital, Huizhou, Guangdong 516007, China

6. College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China

7. Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Funder

Ministry of Science and Technology of the People's Republic of China

Shenzhen Science and Technology Innovation Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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