Probing the Protein–Excipient Interaction in the Orally Delivered Protein by Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry and Molecular Dynamics-Reference-Cited by-同舟云学术

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Probing the Protein–Excipient Interaction in the Orally Delivered Protein by Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry and Molecular Dynamics

Published:2023-12-29 Issue:2 Volume:96 Page:802-809
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Pan Xiao¹,Lenka Sunidhi¹,Davis Jeff²,Nagapudi Karthik²,Mantik Priscilla²,Saggu Miguel¹,Dai Lulu²,Cadang Lance²,Zhang Hui-Min¹^ORCID,Zhang Jennifer¹,Izadi Saeed¹,Yang Feng¹,Wei Bingchuan²^ORCID

Affiliation:

1. Pharmaceutical Technology Development, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Synthetic Molecule Pharmaceutical Science, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c04255

Reference43 articles.

1. Materials for oral delivery of proteins and peptides

2. Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

3. Stabilization of proteins in solid form

4. Stabilization Challenges and Formulation Strategies Associated with Oral Biologic Drug Delivery Systems

5. Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?

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