High-Throughput Screening of Functional Neo-Antigens and Their Specific T-Cell Receptors via the Jurkat Reporter System Combined with Droplet Microfluidics-Reference-Cited by-同舟云学术

High-Throughput Screening of Functional Neo-Antigens and Their Specific T-Cell Receptors via the Jurkat Reporter System Combined with Droplet Microfluidics

Published:2023-06-10 Issue:25 Volume:95 Page:9697-9705
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Li Yijian¹²³,Qi Jingyu²⁴,Liu Yang⁵,Zheng Yuyu²,Zhu Haibin²,Zang Yupeng¹²,Guan Xiangyu¹²,Xie Sichong²,Zhao Hongyan²,Fu Yunyun¹²,Xiang Haitao¹²,Zhang Weicong¹²,Chen Huanyi²,Liu Huan²,Zhao Yuntong²,Feng Yu²,Bu Fanyu²^ORCID,Liang Yanling¹²,Li Yang²,Xu Qumiao²,He Ying⁶,Sun Li⁶,Liu Longqi¹⁷,Gu Ying²⁷,Xu Xun²⁷,Hou Yong¹²,Dong Xuan²³,Liu Ya²⁸^ORCID

Affiliation:

1. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

2. BGI-Shenzhen, Shenzhen 518083, China

3. Guangdong Provincial Key Laboratory of Human Disease Genomics, Shenzhen Key Laboratory of Genomics, Shenzhen 518083, China

4. School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266071, China

5. Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen 518107, China

6. Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China

7. Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen 518120, China

8. Shenzhen Key Laboratory of Single-Cell Omics, BGI-Shenzhen, Shenzhen 518100, China

Funder

National Key Research and Development Program of China

Basic and Applied Basic Research Foundation of Guangdong Province

Shenzhen Key Laboratory of Synthetic Genomics

National Natural Science Foundation of China

Guangdong Provincial Key Laboratory of Human Disease Genomics

China National GeneBank

Guangdong Provincial Key Laboratory of Genome Read and Write

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c01754

Reference25 articles.

1. Facing the future: challenges and opportunities in adoptive T cell therapy in cancer

2. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

3. Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

4. Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II–Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3

5. Driving T-cell immunotherapy to solid tumors

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