Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs-Reference-Cited by-同舟云学术

Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs

Published:2023-06-06 Issue:24 Volume:95 Page:9199-9206
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Cerofolini Linda¹²³,Ravera Enrico¹²³⁴^ORCID,Fischer Christian⁵,Trovato Andrea⁶,Sacco Francesca¹,Palinsky Wolf⁷,Angiuoni Gabriella⁶,Fragai Marco¹²³^ORCID,Baroni Fabio⁶^ORCID

Affiliation:

1. Magnetic Resonance Centre (CERM), University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

2. Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine (CIRMMP), Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

3. Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy

4. Florence Data Science, University of Florence, Viale Morgagni 59, 50134 Florence, Italy

5. Bruker BioSpin GmbH, Rudolf-Planck-Str. 23, 76275 Ettlingen, Germany

6. Analytical Development Biotech Department, Merck Serono S.p.a, an affiliate of Merck KGaA, Darmstadt, Germany, Via Luigi Einaudi 11, 00012 Guidonia, (RM), Italy

7. Biotech Development Programme, Merck Biopharma, an affiliate of Merck KgaA, Darmstadt, Germany, Zone Industrielle de l’Ouriettaz, 1170 Aubonne, Switzerland

Funder

European Commission

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Regione Toscana

H2020 Research Infrastructures

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c00317

Reference52 articles.

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4. Multivariate Analysis of Two-Dimensional 1H, 13C Methyl NMR Spectra of Monoclonal Antibody Therapeutics To Facilitate Assessment of Higher Order Structure

5. Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

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