Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking-Reference-Cited by-同舟云学术

Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-Based Hydrogen–Deuterium Exchange, Cross-linking, and Molecular Docking

Published:2020-05-22 Issue:13 Volume:92 Page:9086-9094
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Zhang Mengru Mira¹^ORCID,Huang Richard Y.-C.²^ORCID,Beno Brett R.³,Deyanova Ekaterina G.²^ORCID,Li Jing²,Chen Guodong²,Gross Michael L.¹^ORCID

Affiliation:

1. Department of Chemistry, Washington University, St. Louis, Missouri 63130, United States

2. Pharmaceutical Candidate Optimization, Nonclinical Research and Development, Bristol Myers Squibb Company, Princeton, New Jersey 08540, United States

3. Molecular Structure & Design, Small Molecule Drug Discovery, Bristol Myers Squibb Company, Princeton, New Jersey 08540, United States

Funder

NIH Office of the Director

Bristol-Myers Squibb

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c01291

Reference49 articles.

1. The Structural Basis of Antibody-Antigen Recognition

2. Current approaches to fine mapping of antigen-antibody interactions

3. Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

4. Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS

5. Hydrogen–Deuterium Exchange Epitope Mapping Reveals Distinct Neutralizing Mechanisms for Two Monoclonal Antibodies against Diphtheria Toxin

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Navigating the landscape of PD-1/PD-L1 imaging tracers: from challenges to opportunities;Frontiers in Medicine;2024-06-07

2. Towards a better understanding of light-glucose induced modifications on the structure and biological activity of formulated Nivolumab;International Journal of Pharmaceutics;2024-04

3. Epitope Mapping of Japanese Encephalitis Virus Neutralizing Antibodies by Native Mass Spectrometry and Hydrogen/Deuterium Exchange;Biomolecules;2024-03-20

4. A molecular dynamics study on the PD-1-Nivolumab interaction: Roles of the N-terminal loop and N58-glycosylation of PD-1;AIP Conference Proceedings;2024

5. Peptide Antibodies: Current Status;Methods in Molecular Biology;2024