Functional Assay to Correlate Protein Oligomerization States with Membrane Pore Formation
Author:
Affiliation:
1. J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 3 182 23 Prague, Czech Republic
2. Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69 120 Heidelberg, Germany
Funder
Deutsche Forschungsgemeinschaft
Grantov? Agentura Cesk? Republiky
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c03276
Reference36 articles.
1. Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2. Molecular biology of Bax and Bak activation and action
3. Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
4. Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species
5. Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores
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