Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody-Reference-Cited by-同舟云学术

Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody

Published:2019-12-09 Issue:1 Volume:92 Page:1582-1588
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Liu Peilu¹²,Gao Xuan³,Lundin Victor¹,Shi Catherine⁴,Adem Yilma⁴,Lin Kevin⁵,Jiang Guoying³,Kao Yung-Hsiang¹,Yang Feng¹^ORCID,Michels David¹,Marshall Alan G.²⁶^ORCID,Zhang Hui-Min¹^ORCID

Affiliation:

1. Proten Analytical Chemistry, Genentech, A Member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States

2. Department of Chemistry and Biochemistry, 95 Chieftain Way, Florida State University, Tallahassee, Florida 32304, United States

3. Biological Technologies, Genentech, A Member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States

4. Pharmaceutical Development, Genentech, A Member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States

5. Analytical Operations, Genentech, A Member of the Roche Group, 1 DNA Way, South San Francisco, California 94080, United States

6. Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, 1800 E. Paul Dirac Drive, Tallahassee, Florida 32310, United States

Funder

Division of Materials Research

State of Florida

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b04855

Reference54 articles.

1. Bispecific antibodies

2. The making of bispecific antibodies

3. Bispecific antibodies for cancer therapy

4. Bispecific antibodies engage T cells for antitumor immunotherapy

5. Recombination of a mixture of univalent antibody fragments of different specificity

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