Oligonucleotide Sequence Mapping of Large Therapeutic mRNAs via Parallel Ribonuclease Digestions and LC-MS/MS-Reference-Cited by-同舟云学术

Oligonucleotide Sequence Mapping of Large Therapeutic mRNAs via Parallel Ribonuclease Digestions and LC-MS/MS

Published:2019-05-26 Issue:13 Volume:91 Page:8500-8506
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Jiang Tao¹^ORCID,Yu Ningxi²,Kim Jaeah³,Murgo John-Ross¹,Kissai Mildred¹,Ravichandran Kanchana¹^ORCID,Miracco Edward J¹,Presnyak Vladimir¹,Hua Serenus¹

Affiliation:

1. Moderna Inc., 500 Technology Square, Cambridge, Massachusetts 02139, United States

2. Department of Chemistry, University of Cincinnati, Cincinnati, Ohio 45221, United States

3. Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602, United States

Funder

Moderna Inc.

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b01664

Reference38 articles.

1. mRNA-based therapeutics — developing a new class of drugs

2. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

3. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

4. Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

5. Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

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