Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond-Reference-Cited by-同舟云学术

Native and Denaturing MS Protein Deconvolution for Biopharma: Monoclonal Antibodies and Antibody–Drug Conjugates to Polydisperse Membrane Proteins and Beyond

Published:2019-06-13 Issue:15 Volume:91 Page:9472-9480
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Campuzano Iain D. G.¹^ORCID,Robinson John H.¹,Hui John O.¹,Shi Stone D.-H.¹,Netirojjanakul Chawita²,Nshanian Michael³,Egea Pascal F.⁴,Lippens Jennifer L.¹,Bagal Dhanashri⁵^ORCID,Loo Joseph A.⁴^ORCID,Bern Marshall⁶

Affiliation:

1. Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Hybrid Modality Engineering, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, California 90095, United States

4. Department of Biological Chemistry, University of California-Los Angeles, Los Angeles, California 90095, United States

5. Discovery Attribute Sciences, Amgen Research, Veterans Boulevard, South San Francisco, California 94080, United States

6. Protein Metrics, Cupertino, California 95010, United States

Funder

National Center for Research Resources

Biological and Environmental Research

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b00062

Reference67 articles.

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4. Twenty Years of Gas Phase Structural Biology

5. Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry

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