DiLeu Isobaric Labeling Coupled with Limited Proteolysis Mass Spectrometry for High-Throughput Profiling of Protein Structural Changes in Alzheimer’s Disease

Author:

Lu Haiyan1,Wang Bin1,Liu Yuan1,Wang Danqing2ORCID,Fields Lauren2ORCID,Zhang Hua1,Li Miyang2,Shi Xudong3,Zetterberg Henrik45678,Li Lingjun129ORCID

Affiliation:

1. School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States

2. Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States

3. Division of Otolaryngology, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin 53792, United States

4. Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 43141 Gothenburg, Sweden

5. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 43130, Sweden

6. Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, U.K.

7. UK Dementia Research Institute at UCL, London WC1N 3BG, U.K.

8. Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong 999077, China

9. Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States

Funder

Alzheimer's Drug Discovery Foundation

Stiftelsen f?r Gamla Tj?narinnor

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute on Aging

Familjen Erling-Perssons Stiftelse

National Institute of General Medical Sciences

Vetenskapsr?det

European Commission

Alzheimer's Association

H2020 Marie Sklodowska-Curie Actions

Hj?rnfonden

University College London

H2020 European Research Council

Olav Thon Stiftelsen

American Society for Mass Spectrometry

Bluefield Project

AD Strategic Fund

Swedish State Support for Clinical Research

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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