Enhanced Detection of Low-Abundance Host Cell Protein Impurities in High-Purity Monoclonal Antibodies Down to 1 ppm Using Ion Mobility Mass Spectrometry Coupled with Multidimensional Liquid Chromatography-Reference-Cited by-同舟云学术

Enhanced Detection of Low-Abundance Host Cell Protein Impurities in High-Purity Monoclonal Antibodies Down to 1 ppm Using Ion Mobility Mass Spectrometry Coupled with Multidimensional Liquid Chromatography

Published:2015-09-10 Issue:20 Volume:87 Page:10283-10291
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Doneanu Catalin E.¹,Anderson Malcolm²,Williams Brad J.³,Lauber Matthew A.¹,Chakraborty Asish¹,Chen Weibin¹

Affiliation:

1. Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757, United States

2. Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, SK9 4AX, U.K.

3. Waters Corporation, 100 Cummings Center, Suite 407N, Beverly, Massachusetts 01915, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5b02103

Reference36 articles.

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3. Evaluation of a high-resolution gas chromatography/high-resolution mass spectrometry method for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in soil and water

4. ICH Harmonised Tripartite Guideline.Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products Q6B, 1999.

5. Identification and quantification of host cell protein impurities in biotherapeutics using mass spectrometry

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