Proteomic Discovery and Development of a Multiplexed Targeted MRM-LC-MS/MS Assay for Urine Biomarkers of Extracellular Matrix Disruption in Mucopolysaccharidoses I, II, and VI

Author:

Heywood Wendy E.1,Camuzeaux Stephane1,Doykov Ivan1,Patel Nina1,Preece Rhian-Lauren1,Footitt Emma2,Cleary Maureen2,Clayton Peter1,Grunewald Stephanie2,Abulhoul Lara2,Chakrapani Anupam2,Sebire Neil J.2,Hindmarsh Peter1,de Koning Tom J.3,Heales Simon24,Burke Derek4,Gissen Paul12,Mills Kevin1

Affiliation:

1. Centre for Translational Omics, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH United Kingdom

2. Centre for Inborn Errors of Metabolism, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, United Kingdom

3. University of Groningen, University Medical Center Groningen, Departments of Genetics and Neurology, P.O. Box 30.001, 9700 RB Groningen, Netherlands

4. Enzyme and Metabolic Unit, Chemical Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, United Kingdom

Funder

Department of Health

University College London

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

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