Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma

Author:

Fu Yunlin1,Xia Yuan-Qing2,Flarakos Jimmy1,Tse Francis L.S.1,Miller Jeffrey D.2,Jones Elliott B.2,Li Wenkui1

Affiliation:

1. Early Bioanalytics and Technology, Drug Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, One Health Plaza, East Hanover, New Jersey 07936, United States

2. Sciex, 500 Old Connecticut Path, Framingham, Massachusetts 01701, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference25 articles.

1. van Breemen, R. B.; Martinez, E. M.Best Practice in Mass Spectrometry for LC-MS Bioanalysis. InHANDBOOK OF LC-MS BIOANALYSIS, Best Practices, Experimental Protocols, and Regulations;Li, Eds.John Wiley & Sons, Inc.:Hoboken, New Jersey, USA, pp205–216.

2. High-throughput bioanalysis of bile acids and their conjugates using UHPLC coupled to HRMS

3. Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides

4. Santa, T.Derivatization in LC-MS Bioanalysis. InHANDBOOK OF LC-MS BIOANALYSIS, Best Practices, Experimental Protocols, and Regulations;Li, Eds.John Wiley & Sons, Inc.:Hoboken, New Jersey, USA, pp239–248.

5. Strategy to Improve the Quantitative LC-MS Analysis of Molecular Ions Resistant to Gas-Phase Collision Induced Dissociation: Application to Disulfide-Rich Cyclic Peptides

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